An Update on Statin Alternatives and Adjuncts
نویسنده
چکیده
and Introduction Abstract LDL cholesterol is the primary target of therapy to lower cardiovascular risk. Statins are medications of first choice to lower LDL cholesterol, but cannot be tolerated in up to 10% of individuals. Intermittent dosing strategies for statins can help reduce muscle symptoms in some patients. A Mediterranean-type diet supplemented with plant stanols and sterols, fiber and fish oils can help achieve cholesterol goals and reduce cardiovascular events. Caution may be needed when using supplements, such as red yeast rice, because of the concern regarding contaminants. Other lipid-lowering medications, such as intestinal agents, niacin and fibrates, can be used as alternative strategies in patients who cannot tolerate statins or in combination with low-dose statins to achieve lipid goals and reduce cardiovascular risk.
منابع مشابه
Update on the clinical utility of fenofibrate in mixed dyslipidemias: mechanisms of action and rational prescribing
Mixed dyslipidemia is a common lipid disorder characterized by the presence of an atherogenic lipoprotein phenotype due to abnormalities in various atherogenic and anti-atherogenic lipoproteins. Despite the link between the decrease of LDL-cholesterol by statin treatment and the prevention of cardiovascular disease, a high residual risk is observed in statin trials. This residual risk is partly...
متن کاملTarget Detection in Bistatic Passive Radars by Using Adaptive Processing Based on Correntropy Cost Function
In this paper a novel method is introduced for target detection in bistatic passive radars which uses the concept of correntropy to distinguish correct targets from false detections. In proposed method the history of each cell of ambiguity function is modeled as a stochastic process. Then the stochastic processes consist the noise are differentiated from those consisting targets by constructing...
متن کاملLipid management after acute coronary syndrome.
PURPOSE OF REVIEW Despite advances in medical therapy and percutaneous revascularization, patients with acute coronary syndrome face a high risk of early, recurrent cardiovascular events. Interventions targeting atherogenic lipoproteins may favorably modify this risk. RECENT FINDINGS Two randomized clinical trials, MIRACL and PROVE-IT, demonstrated efficacy of early, intensive statin therapy ...
متن کاملP149: Statin and Vitamin D as a Prophylactic Medication for Migraine
Migraine is a primary headache disorder that is characterized by severe headaches and impairment of autonomic nervous system function. This neurovascular disorder ranks as the eighth cause of disability in the world. Migraine is basically an inflammation problem caused by activation of the trigeminal neurovascular complex. Neuropeptides like serotonin, calcitonin gene-related peptide (CGRP) and...
متن کاملAlternate-Day Statin Therapy
In a previous article, I discussed adverse drug reactions (ADRs) attributed to statin therapy, specifically myopathies, as well as potential consequences and recommended alternatives. These ADRs are not trivial because they may lead to patient harm in severe cases and/or significant patient nonadherence in most cases. In fact, statins are frequently discontinued as a result of ADRs1,2 and for a...
متن کامل